Genome-wide DNA methylation analysis reveals molecular subtypes of pancreatic cancer.

ABSTRACT: Pancreatic cancer (PC) is the fourth leading cause of cancer deaths in the United States with a five-year patient survival rate of only 6%. Early detection and treatment of this disease is hampered due to lack of reliable diagnostic and prognostic markers. Recent studies have shown that dynamic changes in the global DNA methylation and gene expression patterns play key roles in the PC development; hence, provide valuable insights for better understanding the initiation and progression of PC. In the current study, we used DNA methylation, gene expression, copy number, mutational and clinical data from pancreatic patients. We independently investigated the DNA methylation and differential gene expression profiles between normal and tumor samples and correlated methylation levels with gene ex

SUBMITTER: Mishra NK 

PROVIDER: S-EPMC5438707 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature