Ceruloplasmin as a prognostic marker in patients with bile duct cancer.

ABSTRACT:

Background and aims

Bile duct cancer is one of the lethal cancers, presenting difficulties in early diagnosis and limited treatment modalities. Despite current advances in biomarker research, most studies have been performed in Western populations. Therefore, the purpose of this study was to determine a prognostic marker for bile duct cancer, especially in Korean patients, whose incidence of bile duct cancer is high.

Results

Comparing cancer and normal bile duct tissue, we identified 29091 differentially expressed genes. CP, SCEL, and MUC16 had positive coefficients with a log2 ratio >1 for advanced T, N stage and perineural invasion cancer tissue. Strong immunohistochemical expression of ceruloplasmin was dominant in tumors with advanced T stage (p>0.999) and perineural inv

SUBMITTER: Han IW 

PROVIDER: S-EPMC5438709 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature