GALNT14 genotype as a response predictor for concurrent chemoradiotherapy in advanced esophageal squamous cell carcinoma.

ABSTRACT: Esophageal squamous cell carcinoma is an aggressive cancer. We investigated genetic response predictors for patients with advanced esophageal squamous cell carcinoma receiving concurrent chemoradiotherapy. A cohort of 108 patients was recruited. Survival analysis showed that lower esophageal location of tumor, more advanced metastasis stage, and longer length of tumor were associated with poorer overall survival (adjusted P = 0.001, < 0.001, and 0.045, respectively), while the presence of complete/partial response to concurrent chemoradiotherapy was independently associated with better overall survival (adjusted P < 0.001). The GALNT14-rs9679162 "GG" genotype was associated with a lower rate of response (P = 0.014). Multivariate Cox-proportional hazards models also showed that the "GG" gen

SUBMITTER: Tsou YK 

PROVIDER: S-EPMC5438720 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature