Gas-Phase Oxidation via Ion/Ion Reactions: Pathways and Applications.

ABSTRACT: Here, we provide an overview of pathways available upon the gas-phase oxidation of peptides and DNA via ion/ion reactions and explore potential applications of these chemistries. The oxidation of thioethers (i.e., methionine residues and S-alkyl cysteine residues), disulfide bonds, S-nitrosylated cysteine residues, and DNA to the [M+H+O]⁺ derivative via ion/ion reactions with periodate and peroxymono-sulfate anions is demonstrated. The oxidation of neutral basic sites to various oxidized structures, including the [M+H+O]⁺, [M-H]⁺, and [M-H-NH₃]⁺ species, via ion/ion reactions is illustrated and the oxidation characteristics of two different oxidizing reagents, periodate and persulfate anions, are compared. Lastly, the highly efficient

SUBMITTER: Pilo AL 

PROVIDER: S-EPMC5438755 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature