PREVENT-DM Comparative Effectiveness Trial of Lifestyle Intervention and Metformin.

ABSTRACT:

Introduction

Although the Diabetes Prevention Program and other clinical trials demonstrated the efficacy of intensive lifestyle interventions (ILI) and metformin to prevent type 2 diabetes, no studies have tested their comparative effects in pragmatic settings. This study was designed to compare the real-world effectiveness of ILI, metformin, and standard care among Hispanic women (Latinas) with prediabetes.

Study design

RCT.

Setting/participants

Ninety-two Latinas, who had a mean hemoglobin A1c of 5.9%, BMI of 33.3 kg/m², and waist circumference of 97.4 cm (38.3 inches), were recruited from an urban community and randomly assigned to ILI, metformin, or standard care using 1:1:1 allocation. Data were collected from 2013-2015 and analyzed in 2016.

Interv

SUBMITTER: O'Brien MJ 

PROVIDER: S-EPMC5438762 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature