Ex Vivo Lung Perfusion Rehabilitates Sepsis-Induced Lung Injury.

ABSTRACT:

Background

Sepsis is the number one cause of lung injury in adults. Ex vivo lung perfusion (EVLP) is gaining clinical acceptance for donor lung evaluation and rehabilitation and may expand the use of marginal organs for transplantation. We hypothesized that 4 hours of normothermic EVLP would improve compliance and oxygenation in a porcine model of sepsis-induced lung injury.

Methods

We used intravenous lipopolysaccharide (LPS) to induce a systemic inflammatory response in a porcine model of lung injury. Two groups of 4 animals each received a 2-hour infusion of LPS through the external jugular vein. Serial measurements of blood gases were performed every 30 minutes until the partial pressure of oxygen/fraction of inspired oxygen ratio dropped below 150 on two consecutive rea

SUBMITTER: Mehaffey JH 

PROVIDER: S-EPMC5438908 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature