Cystine addiction of triple-negative breast cancer associated with EMT augmented death signaling.

ABSTRACT: Despite the advances in the diagnosis and treatment of breast cancer, breast cancers still cause significant mortality. For some patients, especially those with triple-negative breast cancer, current treatments continue to be limited and ineffective. Therefore, there remains an unmet need for a novel therapeutic approach. One potential strategy is to target the altered metabolic state that is rewired by oncogenic transformation. Specifically, this rewiring may render certain outside nutrients indispensable. To identify such a nutrient, we performed a nutrigenetic screen by removing individual amino acids to identify possible addictions across a panel of breast cancer cells. This screen revealed that cystine deprivation triggered rapid programmed necrosis, but not apoptosis, in the basal-ty

SUBMITTER: Tang X 

PROVIDER: S-EPMC5438912 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature