Genetic polymorphisms of multidrug and toxin extrusion proteins (MATE1 and MATE2) in South Indian population.

ABSTRACT: Introduction: Drug transporters are key determinants of pharmacokinetic and pharmacodynamic profiles of certain drugs. SLC47A1 (MATE1) and SLC47A2 (MATE2) are major efflux transporters involved in the hepatic and renal excretion of many cationic drugs including metformin. Our study was proposed to determine the normative frequencies of the single nucleotide polymorphisms (SNPs) rs2289669 and rs12943590 in the SLC47A1 and SLC47A2 genes, respectively, in South Indian population and also to compare those with those of the HapMap populations. Methods: One hundred two unrelated healthy volunteers from South India were enrolled in the study. Genomic DNA was extracted by 'phenol-chloroform extraction method' from the peripheral blood leucocytes and genoty

SUBMITTER: Raj GM 

PROVIDER: S-EPMC5439386 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature