Association of Glycemic Variability in Type 1 Diabetes With Progression of Microvascular Outcomes in the Diabetes Control and Complications Trial.

ABSTRACT:

Objective

The Diabetes Control and Complications Trial (DCCT) demonstrated the beneficial effects of intensive versus conventional therapy on the development and progression of microvascular complications of type 1 diabetes. These beneficial effects were almost completely explained by the difference between groups in the levels of HbA_1c, which in turn were associated with the risk of these complications. We assessed the association of glucose variability within and between quarterly 7-point glucose profiles with the development and progression of retinopathy, nephropathy, and cardiovascular autonomic neuropathy during the DCCT.

Research design and methods

Measures of variability included the within-day and updated mean (over time) of the SD, mean amplitude of glyc

SUBMITTER: Lachin JM 

PROVIDER: S-EPMC5439414 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature