Ontology highlight
ABSTRACT:
SUBMITTER: Mishima Y
PROVIDER: S-EPMC5439509 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Cell reports 20170401 1
The development of sensitive and non-invasive "liquid biopsies" presents new opportunities for longitudinal monitoring of tumor dissemination and clonal evolution. The number of circulating tumor cells (CTCs) is prognostic in multiple myeloma (MM), but there is little information on their genetic features. Here, we have analyzed the genomic landscape of CTCs from 29 MM patients, including eight cases with matched/paired bone marrow (BM) tumor cells. Our results show that 100% of clonal mutations ...[more]