A composite measure to explore visual disability in primary progressive multiple sclerosis.

ABSTRACT:

Background

Optical coherence tomography (OCT) and magnetic resonance imaging (MRI) can provide complementary information on visual system damage in multiple sclerosis (MS).

Objectives

The objective of this paper is to determine whether a composite OCT/MRI score, reflecting cumulative damage along the entire visual pathway, can predict visual deficits in primary progressive multiple sclerosis (PPMS).

Methods

Twenty-five PPMS patients and 20 age-matched controls underwent neuro-ophthalmologic evaluation, spectral-domain OCT, and 3T brain MRI. Differences between groups were assessed by univariate general linear model and principal component analysis (PCA) grouped instrumental variables into main components. Linear regression analysis was used to assess the relationship

SUBMITTER: Poretto V 

PROVIDER: S-EPMC5439656 | biostudies-literature | 2017 Apr-Jun

REPOSITORIES: biostudies-literature