Association of cord blood chemokines and other biomarkers with neonatal complications following intrauterine inflammation.

ABSTRACT:

Background

Intrauterine inflammation has been associated with preterm birth and neonatal complications. Few reports have comprehensively investigated multiple cytokine profiles in cord blood and precisely identified surrogate markers for intrauterine inflammation.

Aim

To identify the cytokines and surrogate markers associated with intrauterine inflammation and subsequent neonatal complications.

Patients and methods

We analyzed cord blood samples from 135 patients admitted to the neonatal intensive care unit at Sasebo City General Hospital. We retrospectively determined the associations between the presence of neonatal complications and cord blood cytokines, prenatal factors, and laboratory data at birth. A total of 27 cytokines in the cord blood were measured using a

SUBMITTER: Otsubo Y 

PROVIDER: S-EPMC5439663 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature