Enriching Islet Phospholipids With Eicosapentaenoic Acid Reduces Prostaglandin E₂ Signaling and Enhances Diabetic β-Cell Function.

ABSTRACT: Prostaglandin E₂ (PGE₂) is derived from arachidonic acid, whereas PGE₃ is derived from eicosapentaenoic acid (EPA) using the same downstream metabolic enzymes. Little is known about the impact of EPA and PGE₃ on β-cell function, particularly in the diabetic state. In this work, we determined that PGE₃ elicits a 10-fold weaker reduction in glucose-stimulated insulin secretion through the EP3 receptor as compared with PGE₂ We tested the hypothesis that enriching pancreatic islet cell membranes with EPA, thereby reducing arachidonic acid abundance, would positively impact β-cell function in the diabetic state. EPA-enriched islets isolated from diabetic BTBR Leptin^ob/ob mice produced significantly less PGE

SUBMITTER: Neuman JC 

PROVIDER: S-EPMC5440023 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature