Test-retest reproducibility of quantitative binding measures of [¹¹C]Ro15-4513, a PET ligand for GABA_A receptors containing alpha5 subunits.

ABSTRACT:

Introduction

Alteration of γ-aminobutyric acid "A" (GABA_A) receptor-mediated neurotransmission has been associated with various neurological and psychiatric disorders. [¹¹C]Ro15-4513 is a PET ligand with high affinity for α5-subunit-containing GABA_A receptors, which are highly expressed in limbic regions of the human brain (Sur et al., 1998). We quantified the test-retest reproducibility of measures of [¹¹C]Ro15-4513 binding derived from six different quantification methods (12 variants).

Methods

Five healthy males (median age 40 years, range 38-49 years) had a 90-min PET scan on two occasions (median interval 12 days, range 11-30 days), after injection of a median dose of 441 MegaBequerels of [¹¹C]Ro15-4513. Metabolite-

SUBMITTER: McGinnity CJ 

PROVIDER: S-EPMC5440177 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature