Perusal of parasitic nematode 'omics in the post-genomic era.

ABSTRACT: The advent of high-throughput, next-generation sequencing methods combined with advances in computational biology and bioinformatics have greatly accelerated discovery within biomedical research. This "post-genomics" era has ushered in powerful approaches allowing one to quantify RNA transcript and protein abundance for every gene in the genome - often for multiple conditions. Herein, we chronicle how the post-genomics era has advanced our overall understanding of parasitic nematodes through transcriptomics and proteomics and highlight some of the important advances made in each major nematode clade. We primarily focus on organisms relevant to human health, given that nematode infections significantly impact disability-adjusted life years (DALY) scores within the developing world, but we a

SUBMITTER: Stoltzfus JD 

PROVIDER: S-EPMC5440216 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature