Vagotomy and Parkinson disease: A Swedish register-based matched-cohort study.

ABSTRACT:

Objective

To examine whether vagotomy decreases the risk of Parkinson disease (PD).

Methods

Using data from nationwide Swedish registers, we conducted a matched-cohort study of 9,430 vagotomized patients (3,445 truncal and 5,978 selective) identified between 1970 and 2010 and 377,200 reference individuals from the general population individually matched to vagotomized patients by sex and year of birth with a 40:1 ratio. Participants were followed up from the date of vagotomy until PD diagnosis, death, emigration out of Sweden, or December 31, 2010, whichever occurred first. Vagotomy and PD were identified from the Swedish Patient Register. We estimated hazard ratios (HRs) with 95% confidence intervals (CIs) using Cox models stratified by matching variables, adjusting for cou

SUBMITTER: Liu B 

PROVIDER: S-EPMC5440238 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature