Effect of a long-term intensive lifestyle intervention on prevalence of cognitive impairment.

ABSTRACT:

Objective

To assess whether an average of 10 years of lifestyle intervention designed to reduce weight and increase physical activity lowers the prevalence of cognitive impairment among adults at increased risk due to type 2 diabetes and obesity or overweight.

Methods

Central adjudication of mild cognitive impairment and probable dementia was based on standardized cognitive test battery scores administered to 3,802 individuals who had been randomly assigned, with equal probability, to either the lifestyle intervention or the diabetes support and education control. When scores fell below a prespecified threshold, functional information was obtained through proxy interview.

Results

Compared with control, the intensive lifestyle intervention induced and maintained marked

SUBMITTER: Espeland MA 

PROVIDER: S-EPMC5440245 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature