Pregabalin use early in pregnancy and the risk of major congenital malformations.

ABSTRACT:

Objective

To assess whether first-trimester exposure to pregabalin is associated with an increased risk of major congenital malformations, as recently suggested in a pregnancy registry study.

Methods

We performed a cohort study nested in the US Medicaid Analytic eXtract (MAX). The study population included 1,323,432 pregnancies resulting in a live-born infant between 2000 and 2010. We examined the risk of major congenital malformations among infants born to women exposed to pregabalin during the first trimester compared with women unexposed to anticonvulsants. We used propensity score fine stratification to control for >50 potential confounders, and we estimated relative risks (RRs) and 95% confidence intervals (CIs) in generalized linear models. The analyses were replicated

SUBMITTER: Patorno E 

PROVIDER: S-EPMC5440246 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature