Body mass index is associated with region-dependent metabolic reprogramming of adipose tissue.

ABSTRACT: Adipose tissue (AT) is involved in dysmetabolism pathogenesis. Regional fat distribution and functioning may contribute to obesity-related metabolic disorders and adverse health outcomes. Specific fat depots are suggested to possess unique biological properties, but specific metabolic profiles of subcutaneous (SAT) and visceral adipose tissue (VAT) remain unknown. We aimed to characterize VAT and SAT glucose metabolism, and their correlation with body mass index (BMI). AT samples from patients (n = 12; F:M, 9:3) with a mean age of 46 years (26-83 years) and an average BMI of 29.6 kg/m² (18-37 kg/m²) were used. VAT and SAT explants were obtained during elective laparoscopy, either cholecystectomy for uncomplicated cholelithiasis or gastric bypass for severe obesity. Ex

SUBMITTER: Alves MG 

PROVIDER: S-EPMC5440253 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature