Optimized classification of ¹⁸F-Florbetaben PET scans as positive and negative using an SUVR quantitative approach and comparison to visual assessment.

ABSTRACT:

Introduction

Standardized uptake value ratios (SUVRs) calculated from cerebral cortical areas can be used to categorize ¹⁸F-Florbetaben (FBB) PET scans by applying appropriate cutoffs. The objective of this work was first to generate FBB SUVR cutoffs using visual assessment (VA) as standard of truth (SoT) for a number of reference regions (RR) (cerebellar gray matter (GCER), whole cerebellum (WCER), pons (PONS), and subcortical white matter (SWM)). Secondly, to validate the FBB PET scan categorization performed by SUVR cutoffs against the categorization made by post-mortem histopathological confirmation of the Aβ presence. Finally, to evaluate the added value of SUVR cutoff categorization to VA.

Methods

SUVR cutoffs were generated for each RR using FBB scans from

SUBMITTER: Bullich S 

PROVIDER: S-EPMC5440277 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature