Global transcriptomic analysis of induced cardiomyocytes predicts novel regulators for direct cardiac reprogramming.

ABSTRACT: Heart diseases are the most significant cause of morbidity and mortality in the world. De novo generated cardiomyocytes (CMs) are a great cellular source for cell-based therapy and other potential applications. Direct cardiac reprogramming is the newest method to produce CMs, known as induced cardiomyocytes (iCMs). During a direct cardiac reprogramming, also known as transdifferentiation, non-cardiac differentiated adult cells are reprogrammed to cardiac identity by forced expression of cardiac-specific transcription factors (TFs) or microRNAs. To this end, many different combinations of TFs (±microRNAs) have been reported for direct reprogramming of mouse or human fibroblasts to iCMs, although their efficiencies remain very low. It seems that the investigated TFs and microRNAs are not suf

SUBMITTER: Talkhabi M 

PROVIDER: S-EPMC5440351 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature