Metabolic and Genetic Markers of Biological Age.

ABSTRACT: Biological age is a concept that takes into account the heterogeneity of the aging process in different individuals that results in differences in survival and variations in relative health. Any measure of biological age must be better than chronological age at predicting mortality. Several quantitative measures of biological age have been developed. Among them are frailty indices, one of which called FI₃₄ is discussed here in greater detail. FI₃₄ increases exponentially with age reflecting decline in health and function ability. It readily depicts different patterns and trajectories of aging, and it is moderately heritable. Thus, it has been used to identify a genomic region on chromosome 12 associated with healthy aging. FI₃₄ has also been useful in descr

SUBMITTER: Jazwinski SM 

PROVIDER: S-EPMC5440459 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature