Protein Arginine Methyltransferase 5 Inhibition Upregulates Foxp3⁺ Regulatory T Cells Frequency and Function during the Ulcerative Colitis.

ABSTRACT: Ulcerative colitis (UC) pathogenesis is related to imbalance of immune responses, and the equilibrium between inflammatory T cells and Foxp3⁺ regulatory T cells (Tregs) plays an important role in the intestinal homeostasis. Protein arginine methyltransferases (PRMTs) regulate chromatin remodeling and gene expression. Here, we investigated whether inhibition of PRMTs affects colitis pathogenesis in mice and inflammatory bowel disease patients and further explored the underlying mechanisms. In this study, we found that protein arginine N-methyltransferase inhibitor 1 (AMI-1) treatments increased Tregs frequency, function, and reduced colitis incidence. Adoptive transfer of AMI-1-treated Tregs could reduce the colitis incidence. Colitis was associated with increased local PR

SUBMITTER: Zheng Y 

PROVIDER: S-EPMC5440547 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature