Activity Dependent Modulation of Granule Cell Survival in the Accessory Olfactory Bulb at Puberty.

ABSTRACT: The vomeronasal system (VNS) is specialized in the detection of salient chemical cues triggering social and neuroendocrine responses. Such responses are not always stereotyped, instead, they vary depending on age, sex, and reproductive state, yet the mechanisms underlying this variability are unclear. Here, by analyzing neuronal survival in the first processing nucleus of the VNS, namely the accessory olfactory bulb (AOB), through multiple bromodeoxyuridine birthdating protocols, we show that exposure of female mice to male soiled bedding material affects the integration of newborn granule interneurons mainly after puberty. This effect is induced by urine compounds produced by mature males, as bedding soiled by younger males was ineffective. The granule cell increase induced by mature male

SUBMITTER: Oboti L 

PROVIDER: S-EPMC5440572 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature