Responsiveness to Ipratropium Bromide in Male and Female Patients with Mild to Moderate Chronic Obstructive Pulmonary Disease.

ABSTRACT:

Introduction

Although the prevalence of chronic obstructive pulmonary disease (COPD) is similar between men and women, current evidence used to support bronchodilator therapy has been generated in therapeutic trials that have predominately enrolled male patients. Here, we determined whether there is any significant sex-related differences in FEV₁ responses to ipratropium bromide.

Methods

Data from the Lung Health Study (n=5887; 37% females) were used to determine changes in FEV₁ with ipratropium or placebo in male and female subjects with mild to moderate COPD over 5years. Lung Expression Quantitative Trait Loci (eQTL) dataset was used to determine whether there were any sex-related differences in gene expression for muscarinic (M2 and M3) receptors in

SUBMITTER: Li X 

PROVIDER: S-EPMC5440622 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature