Dynamic diversity of synthetic supramolecular polymers in water as revealed by hydrogen/deuterium exchange.

ABSTRACT: Numerous self-assembling molecules have been synthesized aiming at mimicking both the structural and dynamic properties found in living systems. Here we show the application of hydrogen/deuterium exchange (HDX) mass spectrometry (MS) to unravel the nanoscale organization and the structural dynamics of synthetic supramolecular polymers in water. We select benzene-1,3,5-tricarboxamide (BTA) derivatives that self-assemble in H₂O to illustrate the strength of this technique for supramolecular polymers. The BTA structure has six exchangeable hydrogen atoms and we follow their exchange as a function of time after diluting the H₂O solution with a 100-fold excess of D₂O. The kinetic H/D exchange profiles reveal that these supramolecular polymers in water are dynami

SUBMITTER: Lou X 

PROVIDER: S-EPMC5440672 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature