Effect of age and the APOE gene on metabolite concentrations in the posterior cingulate cortex.

ABSTRACT: Proton magnetic resonance spectroscopy (¹H-MRS) has provided valuable information about the neurochemical profile of Alzheimer's disease (AD). However, its clinical utility has been limited in part by the lack of consistent information on how metabolite concentrations vary in the normal aging brain and in carriers of apolipoprotein E (APOE) ε4, an established risk gene for AD. We quantified metabolites within an 8cm³ voxel within the posterior cingulate cortex (PCC)/precuneus in 30 younger (20-40 years) and 151 cognitively healthy older individuals (60-85 years). All ¹H-MRS scans were performed at 3T using the short-echo SPECIAL sequence and analyzed with LCModel. The effect of APOE was assessed in a sub-set of 130 volunteers. Older participants had signifi

SUBMITTER: Suri S 

PROVIDER: S-EPMC5440729 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature