Proteomic profiling of peripheral blood neutrophils identifies two inflammatory phenotypes in stable COPD patients.

ABSTRACT:

Background

COPD is a heterogeneous chronic inflammatory disease of the airways and it is well accepted that the GOLD classification does not fully represent the complex clinical manifestations of COPD and this classification therefore is not well suited for phenotyping of individual patients with COPD. Besides the chronic inflammation in the lung compartment, there is also a systemic inflammation present in COPD patients. This systemic inflammation is associated with elevated levels of cytokines in the peripheral blood, but the precise composition is unknown. Therefore, differences in phenotype of peripheral blood neutrophils in vivo could be used as a read out for the overall systemic inflammation in COPD.

Method

Our aim was to utilize an unsupervised method to assess the p

SUBMITTER: Loi ALT 

PROVIDER: S-EPMC5440930 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature