LPS-induced systemic inflammation reveals an immunomodulatory role for the prion protein at the blood-brain interface.

ABSTRACT:

Background

The cellular prion protein (PrP^C) is an evolutionary conserved protein abundantly expressed not only in the central nervous system but also peripherally including the immune system. A line of Norwegian dairy goats naturally devoid of PrP^C (PRNP ^Ter/Ter) provides a novel model for studying PrP^C physiology.

Methods

In order to explore putative roles for PrP^C in acute inflammatory responses, we performed a lipopolysaccharide (LPS, Escherichia coli O26:B6) challenge of 16 goats (8 PRNP ^+/+ and 8 PRNP ^Ter/Ter) and included 10 saline-treated controls (5 of each PRNP genotype). Clinical examinations were performed continuously, and blood samples were collected throughout the trial. Genome-wide t

SUBMITTER: Salvesen O 

PROVIDER: S-EPMC5441080 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature