Developmental meta-analysis of the functional neural correlates of autism spectrum disorders.

ABSTRACT:

Objective

There is a pressing need to elucidate the brain-behavior interactions underlying autism spectrum disorders (ASD) given the marked rise in ASD diagnosis over the past decade. Functional magnetic resonance imaging (fMRI) has begun to address this need, but few fMRI studies have evaluated age-related changes in ASD. Therefore, we conducted a developmental analysis of activation likelihood estimation (ALE) meta-analysis to compare child versus adult ASD fMRI studies. We hypothesized that children and adolescents with ASD (<18 years old) would rely less on prefrontal cortex structures than adults (≥18 years old).

Method

PubMed and PsycInfo literature searches were conducted to identify task-dependent fMRI studies of children or adults with ASD. Then recent GingerALE sof

SUBMITTER: Dickstein DP 

PROVIDER: S-EPMC5441228 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature