Meta-analysis of gray matter anomalies in schizophrenia: application of anatomic likelihood estimation and network analysis.

ABSTRACT:

Background

Although structural neuroimaging methods have been widely used to study brain morphology in schizophrenia, synthesizing this literature has been difficult. With the increasing popularity of voxel-based morphometric (VBM) methods in which group differences are reported in standardized coordinates, it is possible to apply powerful meta-analytic techniques initially designed for functional neuroimaging. In this study, we performed a voxelwise, coordinate-based meta-analysis to better conceptualize the neuroanatomic correlates of schizophrenia.

Methods

Thirty-one peer-reviewed articles, with a total of 1195 patients with schizophrenia contrasted with 1262 healthy volunteers, were included in the meta-analysis. Coordinates from each article were used to create a statis

SUBMITTER: Glahn DC 

PROVIDER: S-EPMC5441233 | biostudies-literature | 2008 Nov

REPOSITORIES: biostudies-literature