Linguistic Strategies for Improving Informed Consent in Clinical Trials Among Low Health Literacy Patients.

ABSTRACT:

Background

Improving informed consent to participate in randomized clinical trials (RCTs) is a key challenge in cancer communication. The current study examines strategies for enhancing randomization comprehension among patients with diverse levels of health literacy and identifies cognitive and affective predictors of intentions to participate in cancer RCTs.

Methods

Using a post-test-only experimental design, cancer patients (n = 500) were randomly assigned to receive one of three message conditions for explaining randomization (ie, plain language condition, gambling metaphor, benign metaphor) or a control message. All statistical tests were two-sided.

Results

Health literacy was a statistically significant moderator of randomization comprehension (P = .03). Among p

SUBMITTER: Krieger JL 

PROVIDER: S-EPMC5441300 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature