Does the Implantable Cardioverter-Defibrillator Benefit Vary With the Estimated Proportional Risk of Sudden Death in Heart Failure Patients?

ABSTRACT:

Background

Prediction of which heart failure patients are most likely to die of sudden death vs. non-sudden death is an important factor in determining who will benefit the most from an ICD.

Objective

We developed the Seattle Proportional Risk Model (SPRM) to estimate the proportion of total mortality due to sudden death. We prospectively validated the model in HF-ACTION and tested whether the ICD benefit varied with the SPRM.

Methods

Among 2331 patients enrolled, 1947 patients were retained for analysis over a median follow-up of 2.5 years. The SPRM was calculated using age, gender, diabetes, BMI, SBP, EF, NYHA, sodium, creatinine, and digoxin use.

Results

ICD use (ICD or CRT-D) was present prior to death in 1204 patients (62%). SPRM was predictive of sudden d

SUBMITTER: Levy WC 

PROVIDER: S-EPMC5441395 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature