Evolutionarily conserved serum microRNAs predict radiation-induced fatality in nonhuman primates.

ABSTRACT: Effective planning for the medical response to a radiological or nuclear accident is complex. Because of limited resources for medical countermeasures, the key would be to accurately triage and identify victims most likely to benefit from treatment. We used a mouse model system to provide evidence that serum microRNAs (miRNAs) may effectively predict the impact of radiation on the long-term viability of animals. We had previously used nonhuman primates (NHPs) to demonstrate that this concept is conserved and serum miRNA signatures have the potential to serve as prediction biomarkers for radiation-induced fatality in a human population. We identified a signature of seven miRNAs that are altered by irradiation in both mice and NHPs. Genomic analysis of these conserved miRNAs revealed that th

SUBMITTER: Fendler W 

PROVIDER: S-EPMC5441546 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature