Concordance of bioactive vs. total immunoreactive serum leptin levels in children with severe early onset obesity.

ABSTRACT:

Context

Leptin secreted from adipose tissue signals peripheral energy status to the brain. Monogenic leptin deficiency results in severe early onset obesity with hyperphagia. Recently, a similar phenotype of inactivating leptin mutations but with preserved immunoreactivity and hence normal circulating immunoreactive leptin has been reported.

Objective

We aimed to evaluate the proportion of bioactive leptin serum levels (compared to immunoreactive leptin) as a biomarker for the screening of leptin gene mutations causing monogenic obesity. Furthermore, we aimed to compare the immunoreactive and bioactive leptin levels associations with parameters of insulin resistance and insulin secretion in obese children and adolescents.

Patients and methods

We measured bioactive and

SUBMITTER: Stanik J 

PROVIDER: S-EPMC5441582 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature