Structure of a protective epitope of group B Streptococcus type III capsular polysaccharide.

ABSTRACT: Despite substantial progress in the prevention of group B Streptococcus (GBS) disease with the introduction of intrapartum antibiotic prophylaxis, this pathogen remains a leading cause of neonatal infection. Capsular polysaccharide conjugate vaccines have been tested in phase I/II clinical studies, showing promise for further development. Mapping of epitopes recognized by protective antibodies is crucial for understanding the mechanism of action of vaccines and for enabling antigen design. In this study, we report the structure of the epitope recognized by a monoclonal antibody with opsonophagocytic activity and representative of the protective response against type III GBS polysaccharide. The structure and the atomic-level interactions were determined by saturation transfer differe

SUBMITTER: Carboni F 

PROVIDER: S-EPMC5441712 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature