Early immune responses are independent of RGC dysfunction in glaucoma with complement component C3 being protective.

ABSTRACT: Various immune response pathways are altered during early, predegenerative stages of glaucoma; however, whether the early immune responses occur secondarily to or independently of neuronal dysfunction is unclear. To investigate this relationship, we used the Wld^s allele, which protects from axon dysfunction. We demonstrate that DBA/2J.Wld^s mice develop high intraocular pressure (IOP) but are protected from retinal ganglion cell (RGC) dysfunction and neuroglial changes that otherwise occur early in DBA/2J glaucoma. Despite this, immune pathways are still altered in DBA/2J.Wld^s mice. This suggests that immune changes are not secondary to RGC dysfunction or altered neuroglial interactions, but may be directly induced b

SUBMITTER: Harder JM 

PROVIDER: S-EPMC5441748 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature