Calcium dynamics regulating the timing of decision-making in <i>C. elegans</i>.

ABSTRACT: Brains regulate behavioral responses with distinct timings. Here we investigate the cellular and molecular mechanisms underlying the timing of decision-making during olfactory navigation in Caenorhabditis elegans. We find that, based on subtle changes in odor concentrations, the animals appear to choose the appropriate migratory direction from multiple trials as a form of behavioral decision-making. Through optophysiological, mathematical and genetic analyses of neural activity under virtual odor gradients, we further find that odor concentration information is temporally integrated for a decision by a gradual increase in intracellular calcium concentration ([Ca²⁺]_i), which occurs via L-type voltage-gated calcium channels in a pair of olfactory neurons. In cont

SUBMITTER: Tanimoto Y 

PROVIDER: S-EPMC5441874 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature