Association of Vitamin D Metabolites With Arterial Function in the Hemodialysis Fistula Maturation Study.

ABSTRACT:

Background

Disturbances in vitamin D metabolism are common in patients with end-stage renal disease and may contribute to vascular dysfunction.

Study design

Cross-sectional.

Setting & participants

We evaluated 558 of 602 participants at baseline of the Hemodialysis Fistula Maturation (HFM) Study, a 7-center prospective cohort study of a cohort of patients with chronic kidney disease awaiting arteriovenous fistula (AVF) creation surgery.

Factor

4 vitamin D metabolites measured with liquid chromatography-tandem mass spectroscopy from samples obtained within 4 weeks prior to AVF surgery.

Outcomes

Vasodilator functions and measurements of arterial stiffness.

Measurements

Trained HFM Study personnel measured brachial artery flow-mediated dilation, nitr

SUBMITTER: van Ballegooijen AJ 

PROVIDER: S-EPMC5441944 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature