Modeling the Effect of the Aryl Hydrocarbon Receptor on Transplant Immunity.

ABSTRACT:

Background

Exposure to pollutants through inhalation is a risk factor for lung diseases including cancer, asthma, and lung transplant rejection, but knowledge of the effects of inhaled pollutants on pathologies outside of the lung is limited.

Methods

Using the minor-mismatched model of male C57BL/6J (B6) to female B6 skin grafts, recipient mice were treated with an inhaled urban dust particle sample every 3 days before and after grafting. Graft survival time was determined, and analysis of the resulting immune response was performed at time before rejection.

Results

Significant prolongation of male skin grafts occurred in recipient female mice treated with urban dust particles compared with controls and was found to be dependent on aryl hydrocarbon receptor (AHR) expr

SUBMITTER: Julliard W 

PROVIDER: S-EPMC5441988 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature