Use of Surrogate Samples to Monitor pH During High dose Methotrexate Therapy.

ABSTRACT: High dose methotrexate (Mtx) therapy is commonly used in hemato-oncological practice. Alkalization of urine is a part of high dose methotrexate therapy for preventing crystallization in urine to avert renal insufficiency. Alkalization is monitored by urine pH at regular intervals. Oral pH has occasionally been used as a surrogate for oral mucositis. To compare and correlate pH of various body secretions (venous blood, oral salivary, lacrimal and urine) among patients undergoing alkalization with intravenous sodium bicarbonate during high dose methotrexate therapy. A prospective single center study in patients with hematological malignancies receiving Mtx > 1.5 g/m² over 4-24 h. Patients were assessed for pH (from all 4 body fluids) at regular time intervals (q8 h) starting 6 h-p

SUBMITTER: Yanamandra U 

PROVIDER: S-EPMC5442056 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature