Optimizing radiotherapy protocols using computer automata to model tumour cell death as a function of oxygen diffusion processes.

ABSTRACT: The concept of hypofractionation is gaining momentum in radiation oncology centres, enabled by recent advances in radiotherapy apparatus. The gain of efficacy of this innovative treatment must be defined. We present a computer model based on translational murine data for in silico testing and optimization of various radiotherapy protocols with respect to tumour resistance and the microenvironment heterogeneity. This model combines automata approaches with image processing algorithms to simulate the cellular response of tumours exposed to ionizing radiation, modelling the alteration of oxygen permeabilization in blood vessels against repeated doses, and introducing mitotic catastrophe (as opposed to arbitrary delayed cell-death) as a means of modelling radiation-induced cell death. Publishe

SUBMITTER: Paul-Gilloteaux P 

PROVIDER: S-EPMC5442104 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature