IL-27R signaling controls myeloid cells accumulation and antigen-presentation in atherosclerosis.

ABSTRACT: Myeloid cells, key players in atherosclerosis, take up and present antigens, leading to systemic and local T cell activation. The recruitment and activation of immune cells to the aorta in atherosclerosis is regulated by adhesion molecules, chemokines and cytokines. IL-27R is an immunoregulatory signaling nod in autoimmune and infectious pathologies. IL-27R was shown to suppress T cells activation in atherosclerosis, however it's possible role in myeloid cell accumulation and activation is not understood. Here we demonstrate that Apoe -/- Il27ra -/- mice fed with "Western Diet" for 7 or 18 weeks developed significantly more atherosclerosis compared to Apoe -/- Il27ra +/- controls. Accelerated disease was driven by enhanced expression of adhesion molecules and chemokines causing the accumul

SUBMITTER: Peshkova IO 

PROVIDER: S-EPMC5442117 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature