RANK/RANKL/OPG Signalization Implication in Periodontitis: New Evidence from a RANK Transgenic Mouse Model.

ABSTRACT: Periodontitis is based on a complex inflammatory over-response combined with possible genetic predisposition factors. The RANKL/RANK/OPG signaling pathway is implicated in bone resorption through its key function in osteoclast differentiation and activation, as well as in the inflammatory response. This central element of osteo-immunology has been suggested to be perturbed in several diseases, including periodontitis, as it is a predisposing factor for this disease. The aim of the present study was to validate this hypothesis using a transgenic mouse line, which over-expresses RANK (R^Tg) and develops a periodontitis-like phenotype at 5 months of age. R^Tg mice exhibited severe alveolar bone loss, an increased number of TRAP positive cells, and disorganization of period

SUBMITTER: Sojod B 

PROVIDER: S-EPMC5442248 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature