Distinct patterns of primary and motile cilia in Rathke's cleft cysts and craniopharyngioma subtypes.

ABSTRACT: Cilia are highly conserved organelles, which serve critical roles in development and physiology. Motile cilia are expressed in a limited range of tissues, where they principally regulate local extracellular fluid dynamics. In contrast, primary cilia are expressed by many vertebrate cell types during interphase, and are intimately involved in the cell cycle and signal transduction. Notably, primary cilia are essential for vertebrate hedgehog pathway activity. Improved detection of motile cilia may assist in the diagnosis of some pathologic entities such as Rathke's cleft cysts, whereas characterizing primary cilia in neoplastic tissues may implicate cilia-dependent signaling pathways as critical for tumorigenesis. We show that immunohistochemistry for the nuclear transcription factor FOXJ1,

SUBMITTER: Coy S 

PROVIDER: S-EPMC5442446 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature