SLY regulates genes involved in chromatin remodeling and interacts with TBL1XR1 during sperm differentiation.

ABSTRACT: Sperm differentiation requires unique transcriptional regulation and chromatin remodeling after meiosis to ensure proper compaction and protection of the paternal genome. Abnormal sperm chromatin remodeling can induce sperm DNA damage, embryo lethality and male infertility, yet, little is known about the factors which regulate this process. Deficiency in Sly, a mouse Y chromosome-encoded gene expressed only in postmeiotic male germ cells, has been shown to result in the deregulation of hundreds of sex chromosome-encoded genes associated with multiple sperm differentiation defects and subsequent male infertility. The underlying mechanism remained, to date, unknown. Here, we show that SLY binds to the promoter of sex chromosome-encoded and autosomal genes highly expressed postmeiotically and

SUBMITTER: Moretti C 

PROVIDER: S-EPMC5442469 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature