Phospholipase Cδ1 regulates p38 MAPK activity and skin barrier integrity.

ABSTRACT: Keratinocytes undergo a unique type of programmed cell death known as cornification, which leads to the formation of the stratum corneum (SC), the main physical barrier of the epidermis. A defective epidermal barrier is a hallmark of the two most common inflammatory skin disorders, psoriasis, and atopic dermatitis. However, the detailed molecular mechanisms of skin barrier formation are not yet fully understood. Here, we showed that downregulation of phospholipase C (PLC) δ1, a Ca²⁺-mobilizing and phosphoinositide-metabolizing enzyme abundantly expressed in the epidermis, impairs the barrier functions of the SC. PLCδ1 downregulation also impairs localization of tight junction proteins. Loss of PLCδ1 leads to a decrease in intracellular Ca²⁺ concentrations and nuclear

SUBMITTER: Kanemaru K 

PROVIDER: S-EPMC5442475 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature