Rising prevalence of non-B HIV-1 subtypes in North Carolina and evidence for local onward transmission.

ABSTRACT: HIV-1 diversity is increasing in North American and European cohorts which may have public health implications. However, little is known about non-B subtype diversity in the southern United States, despite the region being the epicenter of the nation's epidemic. We characterized HIV-1 diversity and transmission clusters to identify the extent to which non-B strains are transmitted locally. We conducted cross-sectional analyses of HIV-1 partial pol sequences collected from 1997 to 2014 from adults accessing routine clinical care in North Carolina (NC). Subtypes were evaluated using COMET and phylogenetic analysis. Putative transmission clusters were identified using maximum-likelihood trees. Clusters involving non-B strains were confirmed and their dates of origin were estimated usin

SUBMITTER: Dennis AM 

PROVIDER: S-EPMC5442504 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature