Target-Specific Assay for Rapid and Quantitative Detection of Mycobacterium chimaera DNA.

ABSTRACT: Mycobacterium chimaera is an opportunistic environmental mycobacterium belonging to the Mycobacterium avium-M. intracellulare complex. Although most commonly associated with pulmonary disease, there has been growing awareness of invasive M. chimaera infections following cardiac surgery. Investigations suggest worldwide spread of a specific M. chimaera clone, associated with contaminated hospital heater-cooler units used during the surgery. Given the global dissemination of this clone, its potential to cause invasive disease, and the laboriousness of current culture-based diagnostic methods, there is a pressing need to develop rapid and accurate diagnostic assays specific for M. chimaera Here, we assessed 354 mycobacterial genome sequences and confi

SUBMITTER: Zozaya-Valdes E 

PROVIDER: S-EPMC5442541 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature