Direct Regioselective Synthesis of Tetrazolium Salts by Activation of Secondary Amides under Mild Conditions.

ABSTRACT: Tetrazolium salts are biologically active molecules that have found broad applications in biochemical assays. A regioselective synthesis of tetrazolium salts is described through a formal (3 + 2) cycloaddition. The possibility of employing simple amides and azides as starting material and the mild conditions allow a broad functional group tolerance.

SUBMITTER: Tona V 

PROVIDER: S-EPMC5442602 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature